Kazigore The decoctions of C. Evaluation of antimalarial activity of leaves of Acokanthera schimperi and Croton macrostachyus against Plasmodium berghei in Swiss albino mice. Table 1 Zone of inhibition of the different C. The petals are oblong to oblanceolate, 3—4.
|Published (Last):||27 March 2016|
|PDF File Size:||7.69 Mb|
|ePub File Size:||14.77 Mb|
|Price:||Free* [*Free Regsitration Required]|
Chemical compounds isolated and characterized from Croton macrostachyus. Figure 2 Chemical structures of major compounds isolated from leaves, roots, and stems of Croton macrostachyus. Pharmacological Activities A number of pharmacological activities of C. These pharmacological activities include anthelmintic [ 30 , 95 ], antibacterial [ 53 , 55 , 62 , 85 , 92 , 96 — ], anticonvulsant and sedative [ 50 ], antidiabetic [ 88 ], antidiarrhoeal [ 24 ], antifungal [ 62 , 86 , 92 , ], anti-inflammatory [ 84 , ], antileishmanial [ 94 ], antioxidant [ 86 ], antiplasmodial [ 87 , 89 , , ], antimycobacterial [ ], larvicidal [ 19 , 50 ], and cytotoxicity [ 27 , 43 , 73 , 96 , — ].
Anthelmintic Eguale et al. Both aqueous and hydroalcoholic extracts of C. The aqueous extract of C. Similarly, Aleme et al. These findings indicate that C. Antibacterial Geyid et al. Methanol fruit extract of C. Mesfin et al. Chloroform and n-butanol fractions of C. Wagate et al. The methanolic extracts of C.
In another study, Wagate et al. Croton macrostachyus methanol leaf and root extracts were active against Bacillus cereus with minimum inhibitory concentration MIC value of Tene et al. The ethanol stem bark extract demonstrated some activity with the minimum bactericidal concentration MBC values ranging from The compounds demonstrated some activity with the minimum bactericidal concentration MBC values ranging from The best activity was demonstrated by betulin 1 with MIC value of Belay et al.
Antibacterial activity was demonstrated with minimum inhibitory concentration MIC values ranging from 0. Taye et al. Antibacterial activity was demonstrated by methanol leaf extract against Streptococcus pyogenes with minimum bacterial concentration MBC value of 7. Similarly, Sendeku et al. The leaf extract showed some activity with minimum inhibitory concentrations MIC varying from 3. Recently, Obey et al. These antibacterial activities displayed by different extracts [ 53 , 55 , 62 , 85 , 92 , 96 — ] somehow confirm the potential of C.
Antimycobacterial Gemechu et al. The methanolic leaf extracts of C. The results of this study demonstrate that C. However, further investigations are needed aimed at identifying chemical constituents of C. Antifungal Tene et al. The ethanol stem bark extract demonstrated some activity with the minimum fungicidal concentration MFC values ranging from The compounds demonstrated some activity with the minimum fungicidal concentration MFC values ranging from 7.
The best activity was demonstrated by oxo-hardwickic acid 15 with MIC value of 7. Abera et al. This study indicated the possible use of C. Teugwa et al. All extracts tested showed antifungal activity against the three Trichophyton species tested, with minimum inhibitory concentration MIC and minimum fungicidal concentrations MFC varying from Antidiarrhoeal Degu et al.
The chloroform and methanol fractions produced dose-dependent decline in the weight and volume of intestinal contents while the aqueous fraction did not have a significant effect [ 24 ].
These authors also found that all the fractions produced antimotility effect either at all doses chloroform fraction or at middle and higher doses methanol and aqueous fractions. Anticonvulsant and Sedative Bum et al. Croton macrostachyus also delayed the onset to seizures in the INH test. The decoctions of C. Antidiabetic Arika et al.
Aqueous leaf extract of C. Treatment of diabetic mice with doses of the leaf extract resulted in significantly lower levels of fasting blood glucose and the effects of the leaf extract were comparable with the conventional drugs [ 88 ]. Therefore, the results suggest that C. Anti-Inflammatory Kamanyi et al. Results obtained by Kamanyi et al. Nguelefack et al. Mechanical hyperalgesia was assessed using von Frey hair in awake mice. These studies show that C.
Antileishmanial Gelaw et al. The result of the study revealed that observed IC50 values of crotepoxide 3 to be Antioxidant Teugwa et al. Methanolic leaf extract of C. The documented antioxidant activities of C. Flavonoids and phenolic compounds found in plants are known to have antioxidant properties [ ]. Antiplasmodial Owuor et al. Similarly, Bantie et al. The crude extracts prevented loss of weight and reduction in temperature but did not affect packed cell volume [ 87 ].
In another study, Mohammed et al. Methanol and aqueous extracts of C.
Tinyu PDF Me
Published11 May Abstract In Kenya, leaves and roots from Croton macrostachyus are used as a traditional medicine for infectious diseases such as typhoid and measles, but reports on possible antimicrobial activity of stem bark do not exist. In this study, the antibacterial and antifungal effects of methanol, ethyl acetate and butanol extracts, and purified lupeol of C. The most promising broad scale antimicrobial activity against all the studied pathogens was shown by the ethyl acetate extract. The ethyl acetate extract induced the zone of inhibition between mm and mm against S.