The remainder of this article discusses general concepts pertaining to pulmonary aspergillosis. Pathology The various species of Aspergillus are ubiquitous, and usually do not cause any human pathology, provided the lungs are structurally normal and the host immunity is intact. If either of these is abnormal, then there is the possibility that this otherwise benign fungus may cause pathology. Altered immunity, both heightened hypersensitivity or reduced immunocompromised predisposes to Aspergillus-related lung disease.
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This is a fungi found in the soil. Although most of us are frequently exposed to Aspergillus, a reaction to it is rare in people with normal immune systems. However, in certain people, the immune system overreacts to the antigens of Aspergillus fumigatus found in the lungs. This may damage the airways and result in permanent lung damage.
ABPA most commonly affects people with asthma or cystic fibrosis. Many people with ABPA also suffer from allergic conditions such as atopic dermatitis eczema , urticaria hives , allergic rhinitis hay fever and sinusitis.
Asthma medications such as oral corticosteroids open the airways and make it easier to cough and clear out the fungus. The use of this medication depends upon the individual and the severity of ABPA. The prescription for some people is to take the medication when they have symptoms. Other people with more severe cases of the disease may require daily corticosteroid therapy. In addition, an oral anti-fungal such as itraconazole may be recommended, although it is somewhat controversial regarding its effectiveness.
If you are diagnosed with ABPA, you should be followed closely by your physician in order to prevent or minimize damage to your lungs.
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Allergic Bronchopulmonary Aspergillosis
Allergic Bronchopulmonary Aspergillosis Breathing in a certain type of fungus can cause a negative reaction called allergic bronchopulmomary aspergillosis ABPA. It tends to occur in people with chronic lung conditions, such as asthma and cystic fibrosis. What Causes It? Aspergillus fumigates is a fungus. ABPA occurs when you breathe in this fungus. It causes a chronic reaction that leads to recurring inflammation of the lungs.
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